Incorporating Truncating Variants in PALB2, CHEK2 and ATM into the BOADICEA Breast Cancer Risk Model

PURPOSE: The proliferation of gene-panel testing precipitates the need for a breast cancer (BC) risk model that incorporates the effects of mutations in several genes and family history (FH). We extended the BOADICEA model to incorporate the effects of truncating variants in PALB2, CHEK2 and ATM. ME...

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Publicado en:Genet Med
Main Authors: Lee, Andrew J., Cunningham, Alex P., Tischkowitz, Marc, Simard, Jacques, Pharoah, Paul D., Easton, Douglas F., Antoniou, Antonis C.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086091/
https://ncbi.nlm.nih.gov/pubmed/27464310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2016.31
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