Effects of Mutations on Structure–Function Relationships of Matrix Metalloproteinase-1

Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1 hemopexin-like (HPX) domain have been shown to modulate activity of the MMP-1 catalytic (CAT) domain. In order to reveal the structural and confo...

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Udgivet i:Int J Mol Sci
Main Authors: Singh, Warispreet, Fields, Gregg B., Christov, Christo Z., Karabencheva-Christova, Tatyana G.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085758/
https://ncbi.nlm.nih.gov/pubmed/27754420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17101727
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