Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.

Interleukin 12 (IL-12), produced by myelomonocytic cells, plays a pivotal role in the development of T helper 1 (Th1) cells, which are involved in the pathogenesis of chronic inflammatory autoimmune disorders. 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] inhibits IL-12 production by activated macrophages...

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Autors principals: D'Ambrosio, D, Cippitelli, M, Cocciolo, M G, Mazzeo, D, Di Lucia, P, Lang, R, Sinigaglia, F, Panina-Bordignon, P
Format: Artigo
Idioma:Inglês
Publicat: 1998
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC508562/
https://ncbi.nlm.nih.gov/pubmed/9421488
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