Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity

BM-derived DC (BMDC) are powerful antigen-presenting cells. When loaded with immune complexes (IC), consisting of tumor antigens bound to antitumor antibody, BMDC induce powerful antitumor immunity in mice. However, attempts to employ this strategy clinically with either tumor-associated DC (TADC) o...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Carmi, Yaron, Prestwood, Tyler R., Spitzer, Matthew H., Linde, Ian L., Chabon, Jonathan, Reticker-Flynn, Nathan E., Bhattacharya, Nupur, Zhang, Hong, Zhang, Xiangyue, Basto, Pamela A., Burt, Bryan M., Alonso, Michael N., Engleman, Edgar G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085602/
https://ncbi.nlm.nih.gov/pubmed/27812544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89020
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