GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

Although glutamic acid decarboxylase (GAD) has been implicated in IDDM, there is no direct evidence showing GAD-reactive T cells are diabetogenic in vivo. To address this issue, 3-wk-old NOD mice received two injections of purified rat brain GAD; one mouse rapidly developed diabetes 3 wk later. Sple...

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Hlavní autoři: Zekzer, D, Wong, F S, Ayalon, O, Millet, I, Altieri, M, Shintani, S, Solimena, M, Sherwin, R S
Médium: Artigo
Jazyk:Inglês
Vydáno: 1998
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC508541/
https://ncbi.nlm.nih.gov/pubmed/9421467
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