Structural Basis for Membrane Anchoring of HIV-1 Envelope Spike

HIV-1 envelope spike (Env) is a type I membrane protein that mediates viral entry. We use NMR to determine an atomic structure of the transmembrane (TM) domain of HIV-1 Env reconstituted in bicelles that mimic a lipid bilayer. The TM forms a well-ordered trimer that protects a conserved membrane-emb...

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發表在:Science
Main Authors: Dev, Jyoti, Park, Donghyun, Fu, Qingshan, Chen, Jia, Ha, Heather Jiwon, Ghantous, Fadi, Herrmann, Tobias, Chang, Weiting, Liu, Zhijun, Frey, Gary, Seaman, Michael S., Chen, Bing, Chou, James J.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085267/
https://ncbi.nlm.nih.gov/pubmed/27338706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf7066
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