Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia.

Suppression of endogenous glucose production (EGP) is one of insulin's primary metabolic effects and failure of this action is a major contributor to fasting hyperglycemia of type 2 diabetes mellitus. Classically, insulin was thought to suppress the liver directly, via hyperinsulinemia in the portal...

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Détails bibliographiques

Publié dans:	J Clin Invest
Auteurs principaux:	Mittelman, S D, Fu, Y Y, Rebrin, K, Steil, G, Bergman, R N
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1997
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399959/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119867
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