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Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia.

Suppression of endogenous glucose production (EGP) is one of insulin's primary metabolic effects and failure of this action is a major contributor to fasting hyperglycemia of type 2 diabetes mellitus. Classically, insulin was thought to suppress the liver directly, via hyperinsulinemia in the p...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Mittelman, S D, Fu, Y Y, Rebrin, K, Steil, G, Bergman, R N
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508525/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399959/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119867
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