Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia.

Suppression of endogenous glucose production (EGP) is one of insulin's primary metabolic effects and failure of this action is a major contributor to fasting hyperglycemia of type 2 diabetes mellitus. Classically, insulin was thought to suppress the liver directly, via hyperinsulinemia in the portal...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Mittelman, S D, Fu, Y Y, Rebrin, K, Steil, G, Bergman, R N
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399959/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119867
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