The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.

The antifungal antibiotic clotrimazole (CLT) blocks directly and with high potency the Ca2+-activated K+ channels of human erythrocytes, erythroleukemia cells, and ferret vascular smooth muscle cells. We recently reported that CLT inhibits Cl- secretion in human intestinal T84 cells, likely by affec...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Rufo, P A, Merlin, D, Riegler, M, Ferguson-Maltzman, M H, Dickinson, B L, Brugnara, C, Alper, S L, Lencer, W I
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399958/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119866
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