MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism

The MEK5/ERK5 signaling pathway is emerging as an important contributor to colon cancer onset, progression and metastasis; however, its relevance to chemotherapy resistance remains unknown. Here, we evaluated the impact of the MEK5/ERK5 cascade in colon cancer cell sensitivity to 5-fluorouracil (5-F...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pereira, Diane M., Simões, André E. S., Gomes, Sofia E., Castro, Rui E., Carvalho, Tânia, Rodrigues, Cecília M. P., Borralho, Pedro M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085159/
https://ncbi.nlm.nih.gov/pubmed/27144434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9107
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