MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism

The MEK5/ERK5 signaling pathway is emerging as an important contributor to colon cancer onset, progression and metastasis; however, its relevance to chemotherapy resistance remains unknown. Here, we evaluated the impact of the MEK5/ERK5 cascade in colon cancer cell sensitivity to 5-fluorouracil (5-F...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Pereira, Diane M., Simões, André E. S., Gomes, Sofia E., Castro, Rui E., Carvalho, Tânia, Rodrigues, Cecília M. P., Borralho, Pedro M.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085159/
https://ncbi.nlm.nih.gov/pubmed/27144434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9107
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