Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica

BACKGROUND: More than 220 million people worldwide are chronically infected with schistosomes, causing severe disease or even death. The major pathological damage occurring in schistosomiasis is attributable to the granulomatous inflammatory response and liver fibrosis induced by schistosome eggs. T...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Negl Trop Dis
Auteurs principaux: Zhou, Sha, Jin, Xin, Li, Yalin, Li, Wei, Chen, Xiaojun, Xu, Lei, Zhu, Jifeng, Xu, Zhipeng, Zhang, Yang, Liu, Feng, Su, Chuan
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085144/
https://ncbi.nlm.nih.gov/pubmed/27792733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005094
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