Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica

BACKGROUND: More than 220 million people worldwide are chronically infected with schistosomes, causing severe disease or even death. The major pathological damage occurring in schistosomiasis is attributable to the granulomatous inflammatory response and liver fibrosis induced by schistosome eggs. T...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Zhou, Sha, Jin, Xin, Li, Yalin, Li, Wei, Chen, Xiaojun, Xu, Lei, Zhu, Jifeng, Xu, Zhipeng, Zhang, Yang, Liu, Feng, Su, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085144/
https://ncbi.nlm.nih.gov/pubmed/27792733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005094
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