Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8(+) T cell differentiation

Signals from the T-cell receptor (TCR) and γ-chain cytokine receptors play crucial roles in initiating activation and effector/memory differentiation of CD8 T-cells. We report here that simultaneous deletion of both diacylglycerol kinase (DGK) α and ζ (DKO) severely impaired expansion of CD8 effecto...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Yang, Jialong, Zhang, Ping, Krishna, Sruti, Wang, Jinli, Lin, Xingguang, Huang, Hongxiang, Xie, Danli, Gorentla, Balachandra, Huang, Rick, Gao, Jimin, Li, Qi-Jing, Zhong, Xiao-Ping
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper: Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085116/
https://ncbi.nlm.nih.gov/pubmed/27014906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8164
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