Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

T follicular helper (Tfh) cells play critical roles for germinal center responses and effective humoral immunity. We report here that mTOR in CD4 T cells is essential for Tfh differentiation. In Mtor(f/f)-Cd4Cre mice, both constitutive and inducible Tfh differentiation is severely impaired, leading...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Yang, Jialong, Lin, Xingguang, Pan, Yun, Wang, Jinli, Chen, Pengcheng, Huang, Hongxiang, Xue, Hai-Hui, Gao, Jimin, Zhong, Xiao-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063587/
https://ncbi.nlm.nih.gov/pubmed/27690224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17936
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