Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

Cancer-selective drug delivery is an important concept in improving treatment while minimizing off-site toxicities, and sigma-2 receptors, which are overexpressed in solid tumors, represent attractive pharmacologic targets. Select sigma-2 ligands have been shown to be rapidly internalized selectivel...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Ohman, Kerri A., Hashim, Yassar M., Vangveravong, Suwanna, Nywening, Timothy M., Cullinan, Darren R., Goedegebuure, S. Peter, Liu, Jingxia, Van Tine, Brian A., Tiriac, Herve, Tuveson, David A., DeNardo, David G., Spitzer, Dirk, Mach, Robert H., Hawkins, William G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085100/
https://ncbi.nlm.nih.gov/pubmed/27244881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9551
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