Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

Cancer-selective drug delivery is an important concept in improving treatment while minimizing off-site toxicities, and sigma-2 receptors, which are overexpressed in solid tumors, represent attractive pharmacologic targets. Select sigma-2 ligands have been shown to be rapidly internalized selectivel...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ohman, Kerri A., Hashim, Yassar M., Vangveravong, Suwanna, Nywening, Timothy M., Cullinan, Darren R., Goedegebuure, S. Peter, Liu, Jingxia, Van Tine, Brian A., Tiriac, Herve, Tuveson, David A., DeNardo, David G., Spitzer, Dirk, Mach, Robert H., Hawkins, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085100/
https://ncbi.nlm.nih.gov/pubmed/27244881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9551
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