Development of a 45 kpsi Ultrahigh Pressure Liquid Chromatography Instrument for Gradient Separations of Peptides Using Long Microcapillary Columns and Sub-2 µm Particles

Commercial chromatographic instrumentation for bottom-up proteomics is often inadequate to resolve the number of peptides in many samples. This has inspired a number of complex approaches to increase peak capacity, including various multidimensional approaches, and reliance on advancements in mass s...

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Publicado en:J Chromatogr A
Main Authors: Grinias, Kaitlin M., Godinho, Justin M., Franklin, Edward G., Stobaugh, Jordan T., Jorgenson, James W.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084847/
https://ncbi.nlm.nih.gov/pubmed/27702615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2016.09.053
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