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Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.

The development of preclinical models for the rapid testing of agents that circumvent multidrug resistance in cancer is a high priority of research on drug resistance. A common form of multidrug resistance in human cancer results from expression of the MDR1 gene, which encodes a Mr 170,000 glycoprot...

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Detalhes bibliográficos
Main Authors: Mickisch, G H, Merlino, G T, Galski, H, Gottesman, M M, Pastan, I
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC50848/
https://ncbi.nlm.nih.gov/pubmed/1671173
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