GSK3ß‐dependent dysregulation of neurodevelopment in SPG11‐patient induced pluripotent stem cell model

OBJECTIVE: Mutations in the spastic paraplegia gene 11 (SPG11), encoding spatacsin, cause the most frequent form of autosomal‐recessive complex hereditary spastic paraplegia (HSP) and juvenile‐onset amyotrophic lateral sclerosis (ALS5). When SPG11 is mutated, patients frequently present with spastic...

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Publicado en:Ann Neurol
Main Authors: Mishra, Himanshu K., Prots, Iryna, Havlicek, Steven, Kohl, Zacharias, Perez‐Branguli, Francesc, Boerstler, Tom, Anneser, Lukas, Minakaki, Georgia, Wend, Holger, Hampl, Martin, Leone, Marina, Brückner, Martina, Klucken, Jochen, Reis, Andre, Boyer, Leah, Schuierer, Gerhard, Behrens, Jürgen, Lampert, Angelika, Engel, Felix B., Gage, Fred H., Winkler, Jürgen, Winner, Beate
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084783/
https://ncbi.nlm.nih.gov/pubmed/26971897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24633
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