Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy.

Hepatocellular secretion of bile salts into the biliary space induces phospholipid and cholesterol secretion, but the mechanism for integrated lipid secretion is poorly understood. Knockout mice unable to make the canalicular membrane mdr2 P-glycoprotein exhibit normal rates of bile salt secretion,...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Crawford, A R, Smith, A J, Hatch, V C, Oude Elferink, R P, Borst, P, Crawford, J M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9366571/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119799
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