Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis.

Megalin/gp330 is an endocytic receptor that internalizes multiple ligands including apolipoproteins E (apo E) and B100 (apo B). Megalin is the main antigenic target in passive Heymann nephritis (pHN), where it binds circulating autoantibodies leading to the formation of subepithelial immune deposits...

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Main Authors: Kerjaschki, D, Exner, M, Ullrich, R, Susani, M, Curtiss, L K, Witztum, J L, Farquhar, M G, Orlando, R A
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC508426/
https://ncbi.nlm.nih.gov/pubmed/9410908
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