Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis.

Megalin/gp330 is an endocytic receptor that internalizes multiple ligands including apolipoproteins E (apo E) and B100 (apo B). Megalin is the main antigenic target in passive Heymann nephritis (pHN), where it binds circulating autoantibodies leading to the formation of subepithelial immune deposits...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Kerjaschki, D, Exner, M, Ullrich, R, Susani, M, Curtiss, L K, Witztum, J L, Farquhar, M G, Orlando, R A
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1997
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508426/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9410908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119768
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