Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.

Optimal T cell responsiveness requires signaling through the T cell receptor (TCR) and CD28 costimulatory receptors. Previously, we showed that T cells from autoimmune nonobese diabetic (NOD) mice display proliferative hyporesponsiveness to TCR stimulation, which may be causal to the development of...

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Detalhes bibliográficos
Main Authors: Arreaza, G A, Cameron, M J, Jaramillo, A, Gill, B M, Hardy, D, Laupland, K B, Rapoport, M J, Zucker, P, Chakrabarti, S, Chensue, S W, Qin, H Y, Singh, B, Delovitch, T L
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508420/
https://ncbi.nlm.nih.gov/pubmed/9410902
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