1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production.

We hypothesized that 1,25-dihydroxyvitamin D3 (1,25D3) and its analogues may inhibit acute myelogenous leukemia (AML) proliferation by interrupting IL-1beta-mediated growth-stimulatory signals. The incubation of the IL-1beta- responsive AML cell line OCIM2 with 10 nM 1,25D3 reduced growth 80% in liq...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Peleg, S, Qiu, H, Reddy, S, Harris, D, Van, Q, Estey, E H, Talpaz, M, Estrov, Z
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9312169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119696
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