Foxp2 Controls Synaptic Wiring of Corticostriatal Circuits and Vocal Communication by Opposing Mef2C

Cortico-basal ganglia circuits are critical for speech and language and are implicated in autism spectrum disorder (ASD), in which language function can be severely affected. We demonstrate that in the striatum, the gene, Foxp2, negatively interacts with the synapse suppressor, Mef2C. We present cau...

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Publicado no:Nat Neurosci
Main Authors: Chen, Yi-Chuan, Kuo, Hsiao-Ying, Bornschein, Ulrich, Takahashi, Hiroshi, Chen, Shih-Yun, Lu, Kuan-Ming, Yang, Hao-Yu, Chen, Gui-May, Lin, Jing-Ruei, Lee, Yi-Hsin, Chou, Yun-Chia, Cheng, Sin-Jhong, Chien, Cheng-Ting, Enard, Wolfgang, Hevers, Wulf, Pääbo, Svante, Graybiel, Ann M., Liu, Fu-Chin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083203/
https://ncbi.nlm.nih.gov/pubmed/27595386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4380
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