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The PARP inhibitor ABT-888 potentiates darbazine-induced cell death in carcinoids
Monoagent DNA-alkylating chemotherapies like dacarbazine are among a paucity of medical treatments for advanced carcinoid tumors, but are limited by host toxicity and intrinsic chemoresistance through the base excision repair (BER) pathway via poly (ADP-ribose) polymerase (PARP). Hence, inhibitors o...
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| Publicado no: | Cancer Gene Ther |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5083201/ https://ncbi.nlm.nih.gov/pubmed/27632933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2016.39 |
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