Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4(+) T lymphocytes

Anti-cancer immunotherapies commonly rely on the use of interleukin-2 (IL-2) to promote the expansion of T lymphocytes. IL-2- dependent proliferation is the culmination of a complex network of phosphorylation-driven signaling events that impact on gene transcription through mechanisms that are not c...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Osinalde, Nerea, Mitxelena, Jone, Sánchez-Quiles, Virginia, Akimov, Vyacheslav, Aloria, Kerman, Arizmendi, Jesus M., Zubiaga, Ana M., Blagoev, Blagoy, Kratchmarova, Irina
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083085/
https://ncbi.nlm.nih.gov/pubmed/27067055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.057158
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