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Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.
The treatment of advanced ovarian cancer with taxol is hindered by the development of drug resistance. The cellular target for taxol is the microtubule that is stabilized by the drug. Taxol preferentially binds to the beta subunit of tubulin of which there are six distinct isotypes in mammalian cell...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
1997
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508306/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9276747/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119642 |
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