Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice

To determine whether L-type voltage-operated Ca(2+) channels (L-VOCCs) are required for oligodendrocyte progenitor cell (OPC) development, we generated an inducible conditional knock-out mouse in which the L-VOCC isoform Cav1.2 was postnatally deleted in NG2-positive OPCs. A significant hypomyelinat...

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Publicat a:J Neurosci
Autors principals: Cheli, Veronica T., Santiago González, Diara A., Namgyal Lama, Tenzing, Spreuer, Vilma, Handley, Vance, Murphy, Geoffrey G., Paez, Pablo M.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083013/
https://ncbi.nlm.nih.gov/pubmed/27798140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1770-16.2016
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