Perfluorocarbon-Loaded Lipid Nanocapsules to Assess the Dependence of U87-Human Glioblastoma Tumor pO(2) on In Vitro Expansion Conditions

Growing tumor cell lines, such as U87-MG glioma cells, under mild hypoxia (3% O(2)) leads to a ca. 40% reduction in growth rate once implanted in the brain of nude mice, as compared to normoxia (21% O(2)) grown cells, wherein the former over-express HIF-1 and VEGF-A. Despite developing differently,...

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Udgivet i:PLoS One
Main Authors: Lemaire, Laurent, Nel, Janske, Franconi, Florence, Bastiat, Guillaume, Saulnier, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082913/
https://ncbi.nlm.nih.gov/pubmed/27788227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165479
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