Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.

Graft-versus-host disease (GvHD) is the major limiting toxicity of allogeneic bone marrow transplantation. T cells are important mediators of GvHD, but the molecular mechanisms that they use to induce GvHD are controversial. Three effector pathways have been described for cytotoxic T lymphocytes: on...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Graubert, T A, DiPersio, J F, Russell, J H, Ley, T J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508263/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9259590/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119606
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