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Testing for ROS1 in non-small cell lung cancer: a review with recommendations
Rearrangements of the ROS1 gene occur in 1–2 % of non-small cell lung cancers (NSCLCs). Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the treatment of patients with advanced ROS1-positive NSCLC. Consequently, focus on ROS1 testing is growing. Most laborato...
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Veröffentlicht in: | Virchows Arch |
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Hauptverfasser: | , , , , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
Springer Berlin Heidelberg
2016
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5082594/ https://ncbi.nlm.nih.gov/pubmed/27535289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00428-016-2000-3 |
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