Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease‐related H109R variant

The human dimethylglycine dehydrogenase (hDMGDH) is a flavin adenine dinucleotide (FAD)‐ and tetrahydrofolate (THF)‐dependent, mitochondrial matrix enzyme taking part in choline degradation, one‐carbon metabolism and electron transfer to the respiratory chain. The rare natural variant H109R causes d...

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Detalhes bibliográficos
Publicado no:FEBS J
Main Authors: Augustin, Peter, Hromic, Altijana, Pavkov‐Keller, Tea, Gruber, Karl, Macheroux, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082570/
https://ncbi.nlm.nih.gov/pubmed/27486859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13828
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