Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.

Human respiratory epithelium expresses inducible nitric oxide synthase (iNOS) continuously in vivo, however mechanisms responsible for maintenance of expression are not known. We show that IFNgamma is sufficient for induction of iNOS in primary human airway epithelial cells (HAEC) in vitro, and IL-4...

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Udgivet i:J Clin Invest
Main Authors: Guo, F H, Uetani, K, Haque, S J, Williams, B R, Dweik, R A, Thunnissen, F B, Calhoun, W, Erzurum, S C
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508255/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9259582/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119598
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