Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

Alternative splicing is a regulated process that results in expression of specific mRNA and protein isoforms. Alternative splicing factors determine the relative abundance of each isoform. Here we focus on MBNL1, a splicing factor misregulated in the disease myotonic dystrophy. By altering the conce...

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Publicat a:PLoS Genet
Autors principals: Wagner, Stacey D., Struck, Adam J., Gupta, Riti, Farnsworth, Dylan R., Mahady, Amy E., Eichinger, Katy, Thornton, Charles A., Wang, Eric T., Berglund, J. Andrew
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082313/
https://ncbi.nlm.nih.gov/pubmed/27681373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006316
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