Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

Mouse models of human disease can be generated by homologous recombination for germline loss-of-function mutations. However, embryonic-lethal phenotypes and systemic, indirect dysfunction can confound the use of knock-outs to elucidate adult pathophysiology. Site-specific recombination using Cre rec...

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Pubblicato in:	J Clin Invest
Autori principali:	Agah, R, Frenkel, P A, French, B A, Michael, L H, Overbeek, P A, Schneider, M D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9202069/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119509
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