Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

Mouse models of human disease can be generated by homologous recombination for germline loss-of-function mutations. However, embryonic-lethal phenotypes and systemic, indirect dysfunction can confound the use of knock-outs to elucidate adult pathophysiology. Site-specific recombination using Cre rec...

Cur síos iomlán

Sonraí bibleagrafaíochta

Foilsithe in:	J Clin Invest
Príomhchruthaitheoirí:	Agah, R, Frenkel, P A, French, B A, Michael, L H, Overbeek, P A, Schneider, M D
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	American Society for Clinical Investigation 1997
Ábhair:	Research Article
Rochtain ar líne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9202069/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119509
Clibeanna:	Cuir clib leis Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!