Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element.

To investigate the molecular mechanism(s) by which the estrogen receptor (ER) modulates transcription, we compared the structures of receptor complexes containing estradiol, the agonist diethylstilbestrol, and the antagonist ICI164,384. The binding of ICI164,384 to nontransformed 8-9S ER does not pr...

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Detalles Bibliográficos
Main Authors: Sabbah, M, Gouilleux, F, Sola, B, Redeuilh, G, Baulieu, E E
Formato: Artigo
Idioma:Inglês
Publicado: 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC50816/
https://ncbi.nlm.nih.gov/pubmed/1988939
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