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Cristae remodeling causes acidification detected by integrated graphene sensor during mitochondrial outer membrane permeabilization

The intrinsic apoptotic pathway and the resultant mitochondrial outer membrane permeabilization (MOMP) via BAK and BAX oligomerization, cytochrome c (cytc) release, and caspase activation are well studied, but their effect on cytosolic pH is poorly understood. Using isolated mitochondria, we show th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pham, Ted D., Pham, Phi Q., Li, Jinfeng, Letai, Anthony G., Wallace, Douglas C., Burke, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081517/
https://ncbi.nlm.nih.gov/pubmed/27786282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35907
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