Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats. The sensitization of capsaicin-sensitive TRPV1 io...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Omerbašić, Damir, Smith, Ewan St. J., Moroni, Mirko, Homfeld, Johanna, Eigenbrod, Ole, Bennett, Nigel C., Reznick, Jane, Faulkes, Chris G., Selbach, Matthias, Lewin, Gary R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081396/
https://ncbi.nlm.nih.gov/pubmed/27732851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.035
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