Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice.

Dietary administration of probucol (0.5%, wt/wt) efficiently reduced total plasma cholesterol levels in apolipoprotein E-deficient mice (apoE-/-) by 40%, with decreases in high density lipoprotein (HDL) and apoAI by 70 and 50%, respectively. Paradoxically, however, aortic atherosclerotic plaques in...

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Autors principals: Zhang, S H, Reddick, R L, Avdievich, E, Surles, L K, Jones, R G, Reynolds, J B, Quarfordt, S H, Maeda, N
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC508136/
https://ncbi.nlm.nih.gov/pubmed/9185508
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