IgG subclasses determine pathways of anaphylaxis in mice

BACKGROUND: Animal models have demonstrated that allergen-specific IgG confers sensitivity to systemic anaphylaxis that relies on IgG receptors (FcγRs). Mouse IgG2a and IgG2b bind activating FcγRI, FcγRIII and FcγRIV, and inhibitory FcγRIIB; mouse IgG1 binds only FcγRIII and FcγRIIB. Although these...

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Publié dans:J Allergy Clin Immunol
Auteurs principaux: Beutier, Héloïse, Gillis, Caitlin M., Iannascoli, Bruno, Godon, Ophélie, England, Patrick, Sibilano, Riccardo, Reber, Laurent L., Galli, Stephen J., Cragg, Mark S., Van Rooijen, Nico, Mancardi, David A., Bruhns, Pierre, Jönsson, Friederike
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081282/
https://ncbi.nlm.nih.gov/pubmed/27246523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.03.028
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