Constitutive activation of PI3K in oocyte induces ovarian granulosa cell tumors

Cell-cell interactions play crucial roles in the maintenance of tissue homeostasis, a loss of which often leads to varying diseases, including cancer. Here, we report that uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through perturbe...

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Udgivet i:Cancer Res
Main Authors: Kim, So-Youn, Ebbert, Katherine, Cordeiro, Marilia H., Romero, Megan M., Whelan, Kelly A., Suarez, Adrian A., Woodruff, Teresa K., Kurita, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081136/
https://ncbi.nlm.nih.gov/pubmed/27197196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3358
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