Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

Polycystic kidney diseases (PKDs) comprise a subgroup of ciliopathies characterized by the formation of fluid-filled kidney cysts and progression to end-stage renal disease. A mechanistic understanding of cystogenesis is crucial for the development of viable therapeutic options. Here, we identify CD...

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Publicat a:Hum Mol Genet
Autors principals: Husson, Hervé, Moreno, Sarah, Smith, Laurie A., Smith, Mandy M., Russo, Ryan J., Pitstick, Rose, Sergeev, Mikhail, Ledbetter, Steven R., Bukanov, Nikolay O., Lane, Monica, Zhang, Kate, Billot, Katy, Carlson, George, Shah, Jagesh, Meijer, Laurent, Beier, David R., Ibraghimov-Beskrovnaya, Oxana
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081056/
https://ncbi.nlm.nih.gov/pubmed/27053712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw093
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