Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

Polycystic kidney diseases (PKDs) comprise a subgroup of ciliopathies characterized by the formation of fluid-filled kidney cysts and progression to end-stage renal disease. A mechanistic understanding of cystogenesis is crucial for the development of viable therapeutic options. Here, we identify CD...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Husson, Hervé, Moreno, Sarah, Smith, Laurie A., Smith, Mandy M., Russo, Ryan J., Pitstick, Rose, Sergeev, Mikhail, Ledbetter, Steven R., Bukanov, Nikolay O., Lane, Monica, Zhang, Kate, Billot, Katy, Carlson, George, Shah, Jagesh, Meijer, Laurent, Beier, David R., Ibraghimov-Beskrovnaya, Oxana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081056/
https://ncbi.nlm.nih.gov/pubmed/27053712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw093
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