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Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling
Point mutations to the human gene TPM1 have been implicated in the development of both hypertrophic and dilated cardiomyopathies. Such observations have led to studies investigating the link between single residue changes and the biophysical behavior of the tropomyosin molecule. However, the degree...
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| Publicado no: | Front Physiol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5081029/ https://ncbi.nlm.nih.gov/pubmed/27833562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00473 |
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