The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.

Angiotensin-converting enzyme (ACE) generates the vasoconstrictor angiotensin II, which plays a critical role in maintenance of blood pressure in mammals. Although significant ACE activity is found in plasma, the majority of the enzyme is bound to tissues such as the vascular endothelium. We used ta...

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Main Authors: Esther, C R, Marino, E M, Howard, T E, Machaud, A, Corvol, P, Capecchi, M R, Bernstein, K E
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC508076/
https://ncbi.nlm.nih.gov/pubmed/9153279
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