Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways.

Antigen challenge of sensitized guinea pigs decreases the function of inhibitory M2 muscarinic autoreceptors on parasympathetic nerves in the lung, potentiating vagally induced bronchoconstriction. Loss of M2 receptor function is associated with the accumulation of eosinophils around airway nerves....

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Fryer, A D, Costello, R W, Yost, B L, Lobb, R R, Tedder, T F, Steeber, D A, Bochner, B S
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508029/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9109449/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119372
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