Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis.

Tyrosine kinase-dependent cell signaling is postulated to be a pivotal control point in inflammatory responses initiated by bacterial products and TNF. Using a canine model of gram-negative septic shock, we investigated the effect of tyrosine kinase inhibitors (tyrphostins) on survival. Animals were...

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Main Authors: Sevransky, J E, Shaked, G, Novogrodsky, A, Levitzki, A, Gazit, A, Hoffman, A, Elin, R J, Quezado, Z M, Freeman, B D, Eichacker, P Q, Danner, R L, Banks, S M, Bacher, J, Thomas, M L, Natanson, C
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC508021/
https://ncbi.nlm.nih.gov/pubmed/9109441
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