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Prion-like MAVS aggregation in lupus patients associates with increased interferon-I
OBJECTIVE: Increased levels of Type I interferon (IFN-I) and IFN-I-regulated genes are found in patients with systemic lupus erythematosus (SLE) and may be central to its pathogenesis. The mitochondrial adaptor protein MAVS is a key regulator of IFN-I that undergoes a dramatic prion-like aggregation...
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| Publicado no: | Arthritis Rheumatol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5079845/ https://ncbi.nlm.nih.gov/pubmed/27110677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39733 |
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