Loss of the eIF2α kinase GCN2 protects mice from pressure overload induced congestive heart failure without affecting ventricular hypertrophy

In response to a number of stresses, including nutrient deprivation, General Control Nonderepressible 2 kinase (GCN2) attenuates mRNA translation by phosphorylating eukaryotic initiation factor 2 alpha (eIF2α(Ser51)). Energy starvation is known to exacerbate congestive heart failure (CHF) and eIF2α(...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hypertension
Prif Awduron: Lu, Zhongbing, Xu, Xin, Fassett, John, Kwak, Dongmin, Liu, Xiaoyu, Hu, Xinli, Wang, Huan, Guo, Haipeng, Xu, Dachun, Yan, Shuo, McFalls, Edward O., Lu, Fei, Bache, Robert J., Chen, Yingjie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079623/
https://ncbi.nlm.nih.gov/pubmed/24166753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02313
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